Search details
1.
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Cell
; 184(24): 5886-5901.e22, 2021 11 24.
Article
in English
| MEDLINE | ID: mdl-34822784
2.
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol Cell
; 80(3): 485-500.e7, 2020 11 05.
Article
in English
| MEDLINE | ID: mdl-33027691
3.
Binding of SEP-363856 within TAAR1 and the 5HT1A receptor: implications for the design of novel antipsychotic drugs.
Mol Psychiatry
; 27(1): 88-94, 2022 01.
Article
in English
| MEDLINE | ID: mdl-34376825
4.
Structure-based development of a subtype-selective orexin 1 receptor antagonist.
Proc Natl Acad Sci U S A
; 117(30): 18059-18067, 2020 07 28.
Article
in English
| MEDLINE | ID: mdl-32669442
5.
Multipathway In Vitro Pharmacological Characterization of Specialized Proresolving G Protein-Coupled Receptors.
Mol Pharmacol
; 101(4): 246-256, 2022 04.
Article
in English
| MEDLINE | ID: mdl-35125345
6.
Crystal structure of the M5 muscarinic acetylcholine receptor.
Proc Natl Acad Sci U S A
; 116(51): 26001-26007, 2019 12 17.
Article
in English
| MEDLINE | ID: mdl-31772027
7.
HARVESTMAN: a framework for hierarchical feature learning and selection from whole genome sequencing data.
BMC Bioinformatics
; 22(1): 174, 2021 Apr 01.
Article
in English
| MEDLINE | ID: mdl-33794760
8.
Cryo-EM structure of the dual incretin receptor agonist, peptide-19, in complex with the glucagon-like peptide-1 receptor.
Biochem Biophys Res Commun
; 578: 84-90, 2021 11 12.
Article
in English
| MEDLINE | ID: mdl-34547628
9.
G Protein-Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus.
Pharmacol Rev
; 70(1): 39-67, 2018 01.
Article
in English
| MEDLINE | ID: mdl-29233848
10.
Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?
Mol Psychiatry
; 28(5): 1839-1842, 2023 05.
Article
in English
| MEDLINE | ID: mdl-36932159
11.
Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes.
Mol Pharmacol
; 93(6): 645-656, 2018 06.
Article
in English
| MEDLINE | ID: mdl-29695609
12.
Dynamic allostery governs cyclophilin A-HIV capsid interplay.
Proc Natl Acad Sci U S A
; 112(47): 14617-22, 2015 Nov 24.
Article
in English
| MEDLINE | ID: mdl-26553990
13.
Isoform-Specific Biased Agonism of Histamine H3 Receptor Agonists.
Mol Pharmacol
; 91(2): 87-99, 2017 Feb.
Article
in English
| MEDLINE | ID: mdl-27864425
14.
High throughput, quantitative analysis of human osteoclast differentiation and activity.
Anal Biochem
; 519: 51-56, 2017 Feb 15.
Article
in English
| MEDLINE | ID: mdl-27988276
15.
Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation.
Nature
; 474(7352): 521-5, 2011 May 18.
Article
in English
| MEDLINE | ID: mdl-21593763
16.
International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.
Pharmacol Rev
; 66(4): 918-47, 2014 Oct.
Article
in English
| MEDLINE | ID: mdl-25026896
17.
Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators.
Mol Pharmacol
; 90(4): 427-36, 2016 10.
Article
in English
| MEDLINE | ID: mdl-27461343
18.
HIV-1 Capsid Function Is Regulated by Dynamics: Quantitative Atomic-Resolution Insights by Integrating Magic-Angle-Spinning NMR, QM/MM, and MD.
J Am Chem Soc
; 138(42): 14066-14075, 2016 Oct 26.
Article
in English
| MEDLINE | ID: mdl-27701859
19.
Positive Allosteric Modulation of the Muscarinic M1 Receptor Improves Efficacy of Antipsychotics in Mouse Glutamatergic Deficit Models of Behavior.
J Pharmacol Exp Ther
; 359(2): 354-365, 2016 Nov.
Article
in English
| MEDLINE | ID: mdl-27630144
20.
Automated parameter estimation for biological models using Bayesian statistical model checking.
BMC Bioinformatics
; 16 Suppl 17: S8, 2015.
Article
in English
| MEDLINE | ID: mdl-26679759